Allopurinol and Nutrients Interaction

Common Names: Apo-Allopurinol, Caplenal, Cosuric, Lopurim, Xanthomax, Zyloric

Allopurinol is a xanthine oxidase inhibitor used to prevent gout and to lower blood levels of uric acid in
certain people taking drug for cancer.

Allopurinol interaction with dietary supplements

Vitamin D

               Individuals with gout have low blood concentration of the active form of vitamin D, and allopurinol corrects this problem.
   
L- Carnitine
                     People who have Duchenne muscular dystrophy have low levels of L-Carnitine in their muscles. Allopurinol restores L. Carnitine in their muscles. Allopurinol restores L-Carnitine to normal levels, resulting in improved muscle strength.

L- Tryptophan
                          In a preliminary study, seven of eight individual with severe mental depression showed improvement when they took L. Tryptophan and Allopurinol, of these seven, five experience full remission.

Interactions with Foods and Other Substances
                           
Allopurinol may be taken with food to prevent stomach upset.

Protein:
              Compared with people with high protein diets, people with low protein diets excretes less allopurinol, resulting in a threefold increase in the time it takes for the drug to be removed from the body.
Alcohol
                Alcohol reduces the activity of antioxidant system involving vitamin E, vitamin C, and selenium, leading to the tissue damage in the cerebellum; however, allopurinol reverses the effect. Drinking alcohol beverages also increases the removal of allopurinol from the body, thereby reducing the effectiveness.

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